Monitoring of Altered Free Fatty Acid Metabolic Patterns in Rat Plasma Following Hemorrhagic Stroke

To uncover the physiological changes occurring after hemorrhagic stroke, we analyzed 24 free fatty acids in plasma as tert-butyldimethylsilyl derivatives by gas chromatography-mass spectrometry from control and intracerebral hemorrhage rats. Hematoma volume decreased, and hemorrhage-induced behavioral abnormalities recovered overtime. Altered fatty acid metabolism at 7 days after hemorrhagic stroke spontaneously recovered to normal control levels at 14 days. The deformed star patterns of hemorrhagic stroke group were readily distinguished from the tetracosagonal shape of the control mean. Thus, the present method may be used for monitoring of biochemical and physiological events in hemorrhagic stroke.     

峰值电流达几千安量级的闪电M分量放电特征及机理探讨

利用2009年山东人工触发闪电实验获取的实测雷电流资料、近距离电场和高速摄像资料,分析了6次峰值电流达几千安量级的M分量.6次M分量均对应闪电通道中明显的发光亮度的脉冲式变化,持续时间小于1 ms.M分量的电流波形和近距离电场波形均呈较为对称的V形,且波形的上升时间均为几十微秒,同步记录结果显示,电场先于通道底部电流发生变化且先达到峰值.这些M分量在发生前,闪电通道中存在一定的连续电流,通道的导电性优于先导-回击过程.M分量发生前的闪电 关键词： 闪电 M分量')" href="#">M分量 先导-回击 通道电流     

内源性蛋白质分子成像的研究进展

酰氨质子转移（amide proton transfer, APT）成像是一种新的分子MRI技术,它可用来测量组织中内源性蛋白质. 理论上,APT-MRI信号强度主要取决于游离蛋白质的酰氨质子浓度以及交换速度,而酰氨质子交换速度与组织pH有关. 因此,APT-MRI技术已经被用于无创性中风pH成像（通常pH降低）和肿瘤蛋白质含量成像（通常蛋白质量提高）. 近期对大鼠的实验表明,APT-MRI技术可用来区分放射性坏死和胶质瘤. 该综述文章简要地介绍了APT成像的基本原理以及它在动物模型与临床中风和肿瘤成像中的应用.     

A diethyltartrate-based synthesis of both (−)- and (+)-arundic acid

A diethyltartrate-based synthesis of both enantiomers of the acute ischemic stroke therapeutic agent, arundic acid is presented. Separable diastereomers were obtained through the Johnson-Claisen rearrangement of the chiral vicinal diol based on the diethyltartrate skeleton and were converted separately into the two enantiomers of arundic acid.     

超声心动图结合心电图在鉴别扩张性和缺血性心肌病中的应用

本文对超声心动图（UCG）结合心电图（ECG）在鉴别扩张性心肌病（DCM）和缺血性心肌病（ICM）中的应用价值进行了分析。研究对象为回顾性选取2015年12月~2018年12月本院DCM组和ICM组患者各80例,两组均给予UCG和ECG检查并分析比较其表现。结果显示,DCM组室壁节段性运动障碍、左室心尖圆而薄、左室圆拱门形、室壁矛盾运动发生率明显低于ICM组,DCM组弥漫性室壁运动障碍、左室球形发生率明显高于ICM组,差异有统计学意义（P<0.05）;DCM组左心房内径、左心室舒张期内径、左心室收缩期内径、右心室内径、二尖瓣E点至室间隔间距、E/A、RV6、RV6/RMAX明显高于ICM组,DCM组主动脉、左心室射血分数、每搏量明显低于ICM组,差异有统计学意义（P<0.05）;DCM组主动脉瓣、二尖瓣、三尖瓣反流程度明显高于ICM组,差异有统计学意义（P<0.05）;四格表法结果显示,UCG结合ECG鉴别DCM和ICM的敏感度、特异度、准确度为97.50%、96.25%和96.88%,与实际结果基本相同,差异无统计学意义（P>0.05）。本文证实了UCG结合ECG监测可为鉴别DCM和ICM提供重要的参考依据,可作为鉴别DCM和ICM的重要手段。     

Erythrocyte‐Derived Nanoparticles as a Theranostic Agent for Near‐Infrared Fluorescence Imaging and Thrombolysis of Blood Clots

Ischemic stroke occurs when a blood clot obstructs or narrows the arteries that supply blood to the brain. Currently, tissue plasminogen activator (tPA), a thrombolytic agent, is the only United States Food and Drug Administration (FDA)‐approved pharmacologic treatment for ischemic stroke. Despite its effective usage, the major limitation of tPA that stems from its short half‐life in plasma (≈5 min) is the potential for increased risk of hemorrhagic complications. To circumvent these limitations, herein, the first proof‐of‐principle demonstration of a theranostic nanoconstruct system derived from erythrocytes doped with the FDA‐approved near‐infrared (NIR) imaging agent, indocyanine green, and surface‐functionalized with tPA is reported. Using a clot model, the dual functionality of these nanoconstructs in NIR fluorescence imaging and clot lysis is demonstrated. These biomimetic theranostic nanoconstructs may ultimately be effective in imaging and treatment of blood clots involved in ischemic stroke.     

脑卒中患者血清中钒钼钡铝锶水平的探讨

对１１０名脑卒中患者与对照组血清中钒、钼、钡、铝、锶的含量比较，结果显示：血清锶和钡的含量升高；血清钡和钼的含量降低；而血清铝的含量未见差异。     

脑卒中患者血清中钙镁镉铅铍含量的观察

对１１０例脑卒中患者与正常对照组血清中钙、镁、镉、铅、铍的含量比较。研究结果揭示：血清铍的含量升高，血清钙、镉、铅的含量降低，血清镁的含量两者之间无显著性差异，Ｐ〉０．０５。